First total synthesis of xestobergsterol A and active structural analogues of the xestobergsterols.
نویسندگان
چکیده
[formula: see text] A novel pentacyclic polyhydroxylated sterol, xestobergsterol A (1a), has been synthesized in 24 steps and in good overall yield from stigmasterol 17. The key steps of the synthesis are the Breslow remote functionalization of the polyoxygenated steroid derived from 25 and the base-catalyzed epimerization-aldol condensation of the dione derived from 27.
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ورودعنوان ژورنال:
- Organic letters
دوره 1 10 شماره
صفحات -
تاریخ انتشار 1999